Figure 1

Representative examples of the concordance between brain MRI WMHs and demyelination. (A) Good correlation between radiology and pathology for both periventricular (arrowhead) and deep WM (arrow) lesions; (B) radiological assessment over-estimating periventricular lesions; (C) under-estimating deep WM lesions; (D) over-estimating periventricular lesions and under-estimating deep WM lesions. Radiologic convention, right hemisphere on left hand side. Coronal fluid attenuated inversion recovery (FLAIR) image and corresponding histophatologic slice in Luxol-van Gieson staining with normal WM in green and regions of demyelination in faint green-yellow.