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SVNI versus control
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CBE versus control
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CBE + SVNI versus control
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Statistically significant difference between CBE and SVNI
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Fcrls
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0.2¶ ± 0.0
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3.5 ± 0.2
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2.4 ± 0.1
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Gpr34
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0.5¶ ± 0.1
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2.1 ± 0.2
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1.5 ± 0.1
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Trem2
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0.7 ± 0.1
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5.5 ± 0.4
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3.6 ± 0.8
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Cx3cr1
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0.9 ± 0.1
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2.5 ± 0.1
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2.0 ± 0.3
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Ifi27
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0.9 ± 0.1
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2.6 ± 0.1
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2.4 ± 0.3
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Siglech
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1.0 ± 0.3
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2.2 ± 0.2
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1.9 ± 0.4
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Hexa
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1.2 ± 0.1
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2.1 ± 0.1
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1.7 ± 0.2
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H2-Ob
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1.2 ± 0.4
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4.5 ± 0.8
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4.3 ± 0.9
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Itgb5
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1.3 ± 0.2
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2.3 ± 0.1
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1.9 ± 0.3
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Csf1r
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1.3 ± 0.2
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2.5 ± 0.1
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2.2 ± 0.4
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Cybrd1*
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1.3 ± 0.4
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3.2 ± 0.5
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2.4 ± 0.5
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Cd33
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1.3 ± 0.3
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2.9 ± 0.2
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2.5 ± 0.6
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Hpgds
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1.3 ± 0.2
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2.7 ± 0.3
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1.9 ± 0.4
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Ctsd
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1.4 ± 0.1
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3.1 ± 0.3
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2.2 ± 0.4
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Hexb
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1.5 ± 0.2
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3.2 ± 0.3
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2.7 ± 0.6
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Spp1
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1.5 ± 0.0
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2.1 ± 0.3
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1.5 ± 0.2
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Gusb
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1.7 ± 0.1
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2.4 ± 0.4
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2.0 ± 0.4
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Capn3
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1.9 ± 0.3
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2.6 ± 0.2
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2.3 ± 0.3
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H2-Oa
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2.0 ± 1.2
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5.5 ± 0.2
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4.9 ± 1.5
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Lpar5
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2.1 ± 0.2
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3.0 ± 0.2
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2.7 ± 0.4
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Lilra5
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2.1 ± 0.1
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6.4 ± 1.0
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4.5 ± 1.4
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Not statistically significant difference between CBE and SVNI
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Ang
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1.7 ± 0.5
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2.4 ± 0.6
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1.7 ± 0.6
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Abcc3
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1.7 ± 0.2
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2.3 ± 0.4
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2.1 ± 0.4
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Lpcat2
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1.9 ± 0.2
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2.1 ± 0.1
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1.9 ± 0.4
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Arhgap19
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1.8 ± 0.2
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2.1 ± 0.3
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1.8 ± 0.3
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- RNAseq analysis of brains of control, SVNI, CBE, and CBE + SVNI mice 5 DPI. The numbers indicates fold-change versus control
- ¶Significantly down-regulated (≥ 2.0, fdr ≤ 0.05). Genes in bold font indicate higher expression levels in microglia than all other non-myeloid cells in the CNS. Italicized genes also indicate enrichment in microglia over other myeloid cells
- *Expression at or more highly in astrocytes than other cells in the CNS
