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MCSA (Discovery)
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MCSA (Comparison)
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ADNI (Replication)
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N = 546
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N = 953
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N = 545
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Amyloid positive
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Amyloid negative
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Amyloid positive
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Age (years)
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77.0 (7.7)
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70.0 (9.7)
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76.1 (7.5)
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Sex
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255 (47%) women
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430 (45%) women
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260 (48%) women
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291 (53%) men
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523 (55%) men
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285 (52%) men
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Education (years)
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14.6 (2.8)
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14.9 (2.5)
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15.9 (2.8)
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Median visit number
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4 (1.9)
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5 (1.8)
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4 (1.9)
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APOE ɛ4 status
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317 (58%) negative
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756 (79%) negative
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193 (35%) negative
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229 (42%) positive
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197 (21%) positive
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352 (65%) positive
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Diagnosisa
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458 (85%) CU
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887 (93%) CU
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103 (19%) CU
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78 (14%) MCI
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62 (7%) MCI
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223 (41%) MCI
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6 (1%) Dementia
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1 (0%) Dementia
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214 (40%) Dementia
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- Values displayed as mean (standard deviation) or number (percentage)
- CU cognitively unimpaired, MCI mild cognitive impairment
- aConsensus clinical diagnosis at the first PET/clinical visit; data unavailable for 4 individuals in the MCSA Discovery, 3 individuals in the MCSA Comparison, and 5 individuals in the ADNI replication samples